反応 #82243

反応方程式

5-bromosalicylaldehyde

2-bromo-4-methoxyacetophenone

potassium carbonate

→

5-bromo-2-(4-methoxybenzoyl)benzofuran

収率 42.6%

溶媒

acetone

反応条件

後処理

1. 1
   その他the resulting reaction solution
2. 2
   濃縮was concentrated to dryness
3. 3
   workup.ADDITIONmixed with water
4. 4
   その他to collect
5. 5
   その他precipitated crystals
6. 6
   ろ過by filtration
7. 7
   洗浄After washing with water and subsequent recrystallization from ethanol

実験手順

To 150 ml of acetone were suspended 20 g of 5-bromosalicylaldehyde, 22.9 g of 2-bromo-4-methoxyacetophenone and 27.6 g of anhydrous potassium carbonate. After stirring at room temperature for 4 hours, the resulting reaction solution was concentrated to dryness, and then mixed with water to collect precipitated crystals by filtration. After washing with water and subsequent recrystallization from ethanol, 14.02 g of 5-bromo-2-(4-methoxybenzoyl)benzofuran was obtained in the form of colorless prism crystals.

出典