反応 #82233

反応方程式

methyl 6-hydroxymethyl-5,6,7,8-tetrahydro-2-naphthalenecarboxylate

2,3-dihydropyrane

2,3-dihydropyrane

→

methyl 6-[(2-tetrahydropyranyl)oxymethyl]-5,6,7,8-tetrahydro-2-naphthalenecarboxylate

収率 99.3%

溶媒

diethyl ether

反応条件

後処理

1. 1
   workup.STIRRINGby stirring for 5 hours
2. 2
   その他The resulting reaction mixture
3. 3
   洗浄the mixture was washed with saturated sodium bicarbonate aqueous solution, water and saturated sodium chloride aqueous solution in that order
4. 4
   その他by drying
5. 5
   workup.DISTILLATIONBy distilling off the solvent

実験手順

10.0 g of methyl 6-hydroxymethyl-5,6,7,8-tetrahydro-2-naphthalenecarboxylate was added to 3.82 g of 2,3-dihydropyrane. After further adding 5 drops of concentrated sulfuric acid, the resulting mixture was stirred for 1 hour. To this were further added 1.00 g of 2,3-dihydropyrane and 3 drops of concentrated sulfuric acid, followed by stirring for 5 hours. The resulting reaction mixture was mixed with 100 ml of diethyl ether, and the mixture was washed with saturated sodium bicarbonate aqueous solution, water and saturated sodium chloride aqueous solution in that order, followed by drying. By distilling off the solvent, 13.72 g of methyl 6-[(2-tetrahydropyranyl)oxymethyl]-5,6,7,8-tetrahydro-2-naphthalenecarboxylate was obtained in the form of yellow oil.

出典