反応 #82182

反応方程式

iodine monochloride

sodium sulfite

sodium

1-[2-(4,6-dioxo-2,2-dimethyl-1,3-dioxan-5-yl)ethyl]-2-benzoylpyrrole

1-[2-(4,6-dioxo-2,2-dimethyl-1,3-dioxan-5-yl)ethyl]-2-(benzoyl)pyrrole

sodium

→

Sodium methoxide

4-(2-benzoylpyrrol-1-yl)-2-iodobutyric acid methyl ester

収率 91.5%

溶媒

dichloromethane

methanol

tetrahydrofuran

反応条件

後処理

1. 1
   workup.STIRRINGThe mixture was stirred for 90 minutes at -30° C.
2. 2
   温度to warm to 22° C.
3. 3
   workup.STIRRINGstirred for an additional 18 hours
4. 4
   洗浄the reaction flask was washed with 10 mL of diethyl ether, which
5. 5
   workup.ADDITIONwas added to the separatory funnel
6. 6
   workup.STIRRINGThe mixture was shaken thoroughly
7. 7
   その他the phases were separated
8. 8
   抽出The aqueous phase was extracted with diethyl ether (2×20 mL)
9. 9
   洗浄the combined organic phase was washed with brine
10. 10
    乾燥dried over magnesium sulfate
11. 11
    その他evaporated

実験手順

Sodium methoxide solution was prepared by dissolving metallic sodium (1.38 g, 60 mmol) in methanol (30 mL). This solution was diluted with anhydrous tetrahydrofuran (100 mL) and cooled to -30° C. A solution of iodine monochloride (8.97 g, 55.3 mmol) in dichloromethane (30 mL) was added dropwise to the stirred alkoxide solution. The resulting solution was stirred for 2 minutes, then the sodium salt of 1-[2-(4,6-dioxo-2,2-dimethyl-1,3-dioxan-5-yl)ethyl]-2-benzoylpyrrole (VI, 18.15 g, 50 mmol) was added as a solid. The mixture was stirred for 90 minutes at -30° C., then allowed to warm to 22° C. and stirred for an additional 18 hours. The reaction mixture was poured into 150 mL of 2% aqueous sodium sulfite solution in a separatory funnel, and the reaction flask was washed with 10 mL of diethyl ether, which was added to the separatory funnel. The mixture was shaken thoroughly, and the phases were separated. The aqueous phase was extracted with diethyl ether (2×20 mL), and the combined organic phase was washed with brine, dried over magnesium sulfate, and evaporated to afford 4-(2-benzoylpyrrol-1-yl)-2-iodobutyric acid methyl ester (IV, 18.16 g, 91.5%), identical to the material prepared by the method described above.

出典