反応 #82181

ord-d2e1d505b8404994853be5a3383ad696

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他was kept below 35° C. by application of an external water bath
  2. 2
    workup.WAITAfter 45 minutes
  3. 3
    workup.WAITAfter 20 minutes more
  4. 4
    抽出The resulting mixture was extracted with ether (50 mL)
  5. 5
    抽出saturated with sodium chloride and extracted twice more with ether
  6. 6
    洗浄The combined organic extracts were washed twice with water (50 mL each)
  7. 7
    乾燥once with brine (25 mL), dried over magnesium sulfate
  8. 8
    その他evaporated in vacuo

実験手順

4-(2-Benzoylpyrrol-1-yl)-2-iodobutyric acid methyl ester (IV, 3.17 grams, 8 mmol) was dissolved in dimethylsulfoxide (32 mL). Iron (II) sulfate heptahydrate (230 mg, 0.827 mmol) was added, and the mixture was stirred for 5 minutes. Hydrogen peroxide (30% aqueous solution, 6 mL) was added dropwise while the internal temperature of the reaction was kept below 35° C. by application of an external water bath. After 45 minutes, TLC (4:1 hexane:ethyl acetate, silica) indicated the reaction was about 60% complete. Additional hydrogen peroxide (2 mL) was added. After 20 minutes more, an additional 2 mL of peroxide and 70 mg of iron sulfate were added) and 15 minutes later, an additional 0.5 mL of peroxide. 20 Minutes after the final peroxide addition, the mixture was poured into water (200 mL). The resulting mixture was extracted with ether (50 mL), then saturated with sodium chloride and extracted twice more with ether. The combined organic extracts were washed twice with water (50 mL each), then once with brine (25 mL), dried over magnesium sulfate, and evaporated in vacuo to afford ketorolac methyl ester (2.095 g, still containing traces of ether (1%) and DMSO (<0.3%) by NMR. Yield calculated on the basis of weight and NMR purity is 96%. The product may be crystallized from methanol, m.p. 80°-82° C.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US05621115uspto-grants-1997_04