反応 #82165

ord-bf6dd03f72874cb5bb5ffb7854966443

反応方程式

CC(C)(C)OC(=O)NCC12CN(c3cc4c(cc3F)c(=O)c(C(=O)O)cn4-c3ccc(F)cc3F)CC1CCO2
product
CC(C)(C)OC(=O)NCC12CN(c3cc4c(cc3F)c(=O)c(C(=O)O)cn4-c3ccc(F)cc3F)CC1CCO2
7-(1-tert-butoxycarbonylaminomethyl-2-oxa-7-azabicyclo[3.3.0]oct-7-yl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
Cl
hydrochloric acid
→
Cl.NCC12CN(c3cc4c(cc3F)c(=O)c(C(=O)O)cn4-c3ccc(F)cc3F)CC1CCO2
7-(1-aminomethyl-2-oxa-7-azabicyclo[3.3.0]oct-7-yl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid hydrochloride

反応物

CC(C)(C)OC(=O)NCC12CN(c3cc4c(cc3F)c(=O)c(C(=O)O)cn4-c3ccc(F)cc3F)CC1CCO2
product
CC(C)(C)OC(=O)NCC12CN(c3cc4c(cc3F)c(=O)c(C(=O)O)cn4-c3ccc(F)cc3F)CC1CCO2
7-(1-tert-butoxycarbonylaminomethyl-2-oxa-7-azabicyclo[3.3.0]oct-7-yl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
Cl
hydrochloric acid

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

In an analogous manner to Example 1B, the product from step A is reacted with half-concentrated hydrochloric acid to give 7-(1-aminomethyl-2-oxa-7-azabicyclo[3.3.0]oct-7-yl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid hydrochloride with a melting point of 235° C. (with decomposition).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US05621105uspto-grants-1997_04