反応 #82164

ord-642fa609e641407b934f22d468fd95ba

反応方程式

CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CC4CCOC4(CNC(=O)OC(C)(C)C)C3)c(F)c21
product
CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CC4CCOC4(CNC(=O)OC(C)(C)C)C3)c(F)c21
7-(1-tert-butoxycarbonylaminomethyl-2-oxa-7-azabicyclo[3.3.0]oct-7-yl)-1-ethyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
Cl
hydrochloric acid
→
CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CC4CCOC4(CN)C3)c(F)c21.Cl
7-(1-aminomethyl-2-oxa-7-azabicyclo[3.3.0]oct-7-yl)-1-ethyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid hydrochloride

反応物

CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CC4CCOC4(CNC(=O)OC(C)(C)C)C3)c(F)c21
product
CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CC4CCOC4(CNC(=O)OC(C)(C)C)C3)c(F)c21
7-(1-tert-butoxycarbonylaminomethyl-2-oxa-7-azabicyclo[3.3.0]oct-7-yl)-1-ethyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
Cl
hydrochloric acid

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

In an analogous manner to Example 1B, the product from step A is reacted with half-concentrated hydrochloric acid to give 7-(1-aminomethyl-2-oxa-7-azabicyclo[3.3.0]oct-7-yl)-1-ethyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid hydrochloride with a melting point of 218°-223° C. (with decomposition).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US05621105uspto-grants-1997_04