反応 #82128

反応方程式

N-[2-(3,5-di-tert-butyl-4-hydroxyphenethyl)-4,6-difluorophenyl]-N'-(1-benzyl-4-piperidyl)urea

hydrochloric acid ethyl acetate

→

title compound

収率 81.0%

N-[2-(3,5-di-tert-butyl-4-hydroxyphenethyl)-4,6-difluorophenyl]-N'-(1-benzyl-4-piperidyl)urea hydrochloride

収率 81.0%

溶媒

ethanol

反応条件

後処理

1. 1
   workup.DISSOLUTIONto dissolve it
2. 2
   濃縮This solution was concentrated to a volume of 5 ml
3. 3
   温度cooled to 0°-5° C.
4. 4
   ろ過The resultant crystals were filtered
5. 5
   その他dried

実験手順

N-[2-(3,5-di-tert-butyl-4-hydroxyphenethyl)-4,6-difluorophenyl]-N'-(1-benzyl-4-piperidyl)urea (1.15 g) was suspended in ethanol (20 ml) and heated at 50° C. to dissolve it. To the solution was added 4N hydrochloric acid/ethyl acetate solution (anhydrous)(0.5 ml). This solution was concentrated to a volume of 5 ml, cooled to 0°-5° C. and allowed to stand for 4 hrs. The resultant crystals were filtered and dried to afford the title compound (1.00 g, 81%).

出典