反応 #816016

反応方程式

2-[[2-[4-(1H-imidazol-1-yl)phenoxy]ethyl](phenylmethyl)amino]-1-(2-methoxyphenyl)ethanone

→

title compound

α-[[[2-[4-(1H-Imidazol-1-yl)phenoxy]ethyl]amino]methyl]-2-methoxybenzenemethanol

溶媒

HCl

methanol

反応条件

後処理

1. 1
   その他remove the solvents in vacuo
2. 2
   workup.DISSOLUTIONDissolve the residue in 50 mL H2O with 0.85 9 10% palladium hydroxide on charcoal
3. 3
   その他for 20 h
4. 4
   ろ過After this time, filter the catalyst
5. 5
   その他remove the solvents
6. 6
   その他Recrystallize the solid from ethanol

実験手順

Dissolve 3.8 9 2-[[2-[4-(1H-imidazol-1-yl)phenoxy]ethyl](phenylmethyl)amino]-1-(2-methoxyphenyl)ethanone in 50 mL 5 M HCl in methanol and remove the solvents in vacuo. Dissolve the residue in 50 mL H2O with 0.85 9 10% palladium hydroxide on charcoal. Hydrogenate the solution under 52 psi hydrogen for 20 h. After this time, filter the catalyst and remove the solvents to givethe crude product. Recrystallize the solid from ethanol to give the title compound.

出典