反応 #815920
ord-d2a245c33e344359bb69c7b11587fd4d
反応条件
詳細条件
See reaction.notes.procedure_details.
後処理
- 1濃縮The mixture was concentrated
- 2洗浄washed 2 times with water
- 3乾燥dried with Na2SO4
- 4濃縮concentrated
実験手順
9-Decen-1-ol (25.0 g, 160 mmol) was dissolved in a solution made up of t-butanol (100 ml), acetone (90 ml) and water (10 ml). To this solution was added trimethylamine-N-oxide (26.6 g, 240 mmol) and 2 ml of a solution of osmium tetroxide (500 mg) in t-butanol (25 ml). The resulting solution was stirred 20 hours under nitrogen then 10% sodium bisulfite was added (50 ml). The mixture was concentrated, then taken up in trichloromethane and washed 2 times with water, dried with Na2SO4 and concentrated to give 1,2,10-decanetriol as an oil. This material was used without further purification in preparation of the corresponding acetonide (of formula 21).