反応 #81530

反応方程式

THF

traumatic acid

triethylamine

THF

ethanolamine

→

N,N'-bis-(2-hydroxyethyl)-trans-2-dodecendiamide

反応条件

後処理

1. 1
   その他in 30 minutes
2. 2
   温度The mixture was maintained
3. 3
   workup.STIRRINGunder stirring at -10° C. for 2 hours and subsequently at 0° C. for 15 hours
4. 4
   その他in 30 minutes

実験手順

A solution of 5.74 g isobutylchloroformiate (42 mmol) in 50 ml THF was slowly added drop by drop in 30 minutes to a mixture containing 4.57 g traumatic acid (20 mmol) and 4.26 g triethylamine (42 mmol) in 150 ml anhydrous THF under stirring at -10° C. The mixture was maintained under stirring at -10° C. for 2 hours and subsequently at 0° C. for 15 hours. 3.5 g ethanolamine were slowly added drop by drop in 30 minutes.

出典