反応 #81527

反応方程式

[1-(1-methylethyl)-4-piperidinyl]methyl[2-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]carbamate

ethyl acetate

maleic acid

→

title compound

収率 70.9%

[1-(1-Methylethyl)-4-piperidinyl]methyl[2-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]carbamate Maleate

収率 70.9%

溶媒

methanol

反応条件

後処理

1. 1
   濃縮Concentration in vacuo
2. 2
   workup.WAITleft a white oily residue which
3. 3
   その他was triturated twice in ether (10 ml)
4. 4
   ろ過The resulting white powder was filtered
5. 5
   その他dried in vacuo

実験手順

To a warm solution of [1-(1-methylethyl)-4-piperidinyl]methyl[2-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]carbamate (120 mg) in the minimum amount of ethyl acetate was added a solution of maleic acid (36.9 mg) in the minimum amount of warm methanol (2 ml). Concentration in vacuo left a white oily residue which was triturated twice in ether (10 ml). The resulting white powder was filtered and dried in vacuo to yield the title compound as a light brown solid (107 mg), m.p. 89°-93°.

出典