反応 #8147

反応方程式

2-fluoro-4-(3-diethylamino-1-propoxy)nitrobenzene

n-butylamine

→

2-n-butylamino-4-(3-diethylamino-1-propoxy)nitrobenzene

溶媒

THF

反応条件

後処理

1. 1
   その他After completion of the reaction
2. 2
   濃縮the reaction mixture is concentrated in vacuo
3. 3
   workup.DISSOLUTIONThe residue is redissolved in EtOAc (10 mL)
4. 4
   洗浄washed with saturated sodium bicarbonate solution, water, and brine
5. 5
   乾燥The organic phase is then dried over sodium sulfate
6. 6
   その他the solvent is removed in vacuo

実験手順

A solution of 2-fluoro-4-(3-diethylamino-1-propoxy)nitrobenzene (2 mmol; preparation described in Example 5) in THF (5 mL) is treated with n-butylamine (2.4 eq) at rt. After completion of the reaction, the reaction mixture is concentrated in vacuo. The residue is redissolved in EtOAc (10 mL), washed with saturated sodium bicarbonate solution, water, and brine. The organic phase is then dried over sodium sulfate and the solvent is removed in vacuo to afford the product, 2-n-butylamino-4-(3-diethylamino-1-propoxy)nitrobenzene (580 mg) which was used for further transformation without further purification.

出典