反応 #81468
ord-94d92c56bf574920853a00aa70205454
反応方程式
反応条件
詳細条件
See reaction.notes.procedure_details.
後処理
- 1その他had formed
- 2ろ過The mixture was then filtered
- 3濃縮the filtrate concentrated
- 4その他to afford the crude product which
- 5その他was recrystallised firstly from ethanol/water (1:1)
実験手順
To a stirred suspension of finely powdered 17-(3-pyridyl)androsta-5,16-dien-3β-ol (3.50 g, 10 mmol) in dry diethyl ether (150 ml) coning triethylamine (2,3 ml, 16 mmol) and dimethylaminopyridine (0.012 g, 0.1 mmol) was added acetyl chloride (1.0 ml, 14 mmol). The mixture was then stirred at ambient temperature for 12 h, over which time a thick whim precipitate of triethylammonium chloride had formed. The mixture was then filtered and the filtrate concentrated to afford the crude product which was recrystallised firstly from ethanol/water (1:1), then finally from hexane to afford the title compound (3.30 g, 84%).