反応 #8146

反応方程式

nitro

2-fluoro-4-(3-diethylamino-1-propoxy)nitrobenzene

ammonium carbonate

EtOAc

→

2-nitro-5-(3-diethylamino-1-propoxy)aniline

溶媒

DMF

反応条件

後処理

1. 1
   洗浄The combined organic layers are then washed with water and brine
2. 2
   乾燥dried over Na2SO4
3. 3
   その他Removal of the solvent in vacuo

実験手順

The nitro compound obtained as above (1.5 mmol) is dissolved in DMF (4 mL) and added with ammonium carbonate (500 mg). The reaction mixture is then heated at 80° C. for 48 h. EtOAc (2×10 mL). The combined organic layers are then washed with water and brine and dried over Na2SO4. Removal of the solvent in vacuo yielded the 2-nitro-5-(3-diethylamino-1-propoxy)aniline (300 mg) which is used for further transformation without any purification.

出典