反応 #81452

反応方程式

compound

5-benzyl-3,3-dibromo-1-methyl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one

acetic acid

→

title product

収率 60.0%

5-benzoyl-1-methyl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one

収率 60.0%

反応条件

後処理

1. 1
   濃縮concentrate to dryness under reduced pressure
2. 2
   抽出extract with dichloromethane
3. 3
   その他The crude product obtained
4. 4
   濃縮by concentrating to dryness
5. 5
   その他is purified by chromatography on a silica column (eluant: petroleum ether/ethyl acetate, 6/4)

実験手順

Add a spatula tip of zinc to a solution of 40 mg of the compound of Step 2 in acetic acid. After 30 minutes' stirring, concentrate to dryness under reduced pressure, take up in water and extract with dichloromethane. The crude product obtained by concentrating to dryness is purified by chromatography on a silica column (eluant: petroleum ether/ethyl acetate, 6/4). The title product is obtained in the form of an oil in a yield of 60%. ##STR63##

出典