反応 #81297

反応方程式

sodium hydride

2-butylimidazole-4,5-dicarbonitrile

ethyl acetate

trityl chloride

→

title compound

収率 82.2%

2-Butyl-1-tritylimidazole-4,5-dicarbonitrile

収率 82.2%

溶媒

N,N-dimethylformamide

water

反応条件

後処理

1. 1
   workup.STIRRINGthe reaction mixture was stirred at 50° C. for 6 hours
2. 2
   抽出the product was extracted with ethyl acetate
3. 3
   乾燥The extract was dried over anhydrous magnesium sulfate
4. 4
   その他the solvent was removed by distillation under reduced pressure
5. 5
   その他The resulting residue was purified by column chromatography through silica gel
6. 6
   workup.ADDITIONby volume mixture of ethyl acetate and hexane as the eluent

実験手順

1.25 g of sodium hydride (as a 55% w/w dispersion in mineral oil) were added, whilst ice-cooling, to a solution of 5 g of 2-butylimidazole-4,5-dicarbonitrile (prepared as described in Preparation 1) in 50 ml of N,N-dimethylformamide, and the resulting mixture was stirred for 15 minutes. 10 g of trityl chloride were then added, and the reaction mixture was stirred at 50° C. for 6 hours. At the end of this time, it was mixed with ethyl acetate and water, and the product was extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate, and the solvent was removed by distillation under reduced pressure. The resulting residue was purified by column chromatography through silica gel, using a 1:5 by volume mixture of ethyl acetate and hexane as the eluent, to give 9.83 g of the title compound as a syrup, which solidified on being allowed to stand. The solid melted at 144°-147° C. (with decomposition and coloration at 94°-98° C.).

出典