反応 #812841

反応方程式

4-(2-tert-butoxycarbonylaminoethyl)-piperidine

triethylamine

acetyl chloride

→

title compound

N-Acetyl-4-(2-tert-butoxycarbonylaminoethyl)-piperidine

溶媒

dichloromethane

反応条件

後処理

1. 1
   洗浄washed with water
2. 2
   濃縮The organic phase is concentrated by evaporation
3. 3
   その他purified by FC (10 g of silica gel, ethyl acetate/methanol=9:1)

実験手順

0.5 g of 4-(2-tert-butoxycarbonylaminoethyl)-piperidine and 0.61 ml of triethylamine are dissolved in 5 ml of dichloromethane and, at 0° C., 0.22 ml of acetyl chloride is added. The reaction mixture is stirred at room temperature for 7 hours and then washed with water. The organic phase is concentrated by evaporation and purified by FC (10 g of silica gel, ethyl acetate/methanol=9:1). The title compound is obtained: Rf (ethyl acetate/methanol=9:1)=0.39.

出典