反応 #81244

反応方程式

ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate

4'-bromomethylbiphenyl-2-carboxylate

potassium t-butoxide

→

title compound

収率 74.1%

Ethyl 1-[(2'-t-butoxycarbonylbiphenyl-4-yl)methyl]-4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate

収率 74.1%

反応条件

実験手順

Following a procedure similar to that described in Example 68(a), but using 4.80 g of ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate (prepared as described in Preparation 9), 6.94 g of t-buryl 4'-bromomethylbiphenyl-2-carboxylate and 2.28 g of potassium t-butoxide, 7.50 g of the title compound were obtained as crystals, melting at 90°-91° C.

出典