反応 #81172

反応方程式

ethyl 2-butyl-4-(1-ethyl-1-hydroxypropyl)imidazole-5-carboxylate

sodium hydride

4-[2-(trityltetrazol-5-yl)phenyl]benzyl bromide

→

title compound

収率 52.1%

Ethyl 2-butyl-4-(1-ethyl-1-hydroxypropyl)-1-{4 -[2-(trityltetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate

収率 52.1%

反応条件

実験手順

Following a procedure similar to that described in Example 18(a), but using 0.75 g of ethyl 2-butyl-4-(1-ethyl-1-hydroxypropyl)imidazole-5-carboxylate (prepared as described in Preparation 13), 0.12 g of sodium hydride (as a 55% w/w dispersion in mineral oil) and 1.51 g of 4-[2-(trityltetrazol-5-yl)phenyl]benzyl bromide, there were obtained 1.05 g of the title compound as an amorphous solid.

出典