反応 #81168

反応方程式

ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate

t-butyl 4'-bromomethylbiphenyl-2-carboxylate

→

title compound

収率 73.6%

Ethyl 1-[(2'-t-butoxycarbonylbiphenyl-4-yl)methyl]-4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate

収率 73.6%

反応条件

実験手順

Following a procedure similar to that described in Example 1(a), but using 0.845 g of ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate (prepared as described in Preparation 9) and 1.22 g of t-butyl 4'-bromomethylbiphenyl-2-carboxylate, 1.31 g of the title compound were obtained as a gum. This compound was allowed to stand at room temperature, which caused it to crystallize. It was then recrystallized from a mixture of diisopropyl ether and hexane, to give pure title compound, melting at 90°-91° C.

出典