反応 #81080

反応方程式

(S)-2-Phthalimido-5,5-dimethoxypentanoic acid, methyl ester

hydrazine monohydrate

→

title product

(S)-2-Amino-5,5-dimethoxypentanoic acid, methyl ester

溶媒

methanol

反応条件

後処理

1. 1
   ろ過The mixture was filtered
2. 2
   洗浄the solid was washed with methanol
3. 3
   濃縮The filtrate was concentrated
4. 4
   その他triturated with methylene chloride
5. 5
   ろ過filtered again
6. 6
   濃縮concentrated
7. 7
   その他dried in vacuo
8. 8
   その他to yield 1.89 g

実験手順

(S)-2-Phthalimido-5,5-dimethoxypentanoic acid, methyl ester [prepared as described in Example 4(f), 3.35 g., 10.43 mmol.) in methanol (70 ml.) was treated with hydrazine monohydrate (531 μl., 10.95 mmol., 1.05 eq.) and the solution was stirred at room temperature for 6 days. The mixture was filtered and the solid was washed with methanol. The filtrate was concentrated, triturated with methylene chloride, filtered again, concentrated, and dried in vacuo to yield 1.89 g. of title product as a cloudy oil. TLC (10% methanol in methylene chloride) Rf =0.39.

出典