反応 #810459

反応方程式

imidazole

2-[2-(2-methoxyethoxy)ethoxy]ethyl p-toluenesulfonate

potassium carbonate

N,N-dimethylformamide

→

1-[2-[2-(2-methoxyethoxy)ethoxy]ethyl]-1H-imidazole

収率 76.2%

溶媒

ethyl acetate

反応条件

後処理

1. 1
   温度was heated
2. 2
   ろ過The precipitate was filtered off
3. 3
   workup.DISTILLATIONafter which the solvent was distilled off in vacuo
4. 4
   workup.DISTILLATIONThe residue was purified by distillation in vacuo

実験手順

In a nitrogen atmosphere, a mixture of 68.0 g of imidazole, 318 g of 2-[2-(2-methoxyethoxy)ethoxy]ethyl p-toluenesulfonate, 276 g of potassium carbonate, and 1,000 g of N,N-dimethylformamide was heated and stirred at 100° C. for 16 hours. To the reaction solution was added ethyl acetate. The precipitate was filtered off, after which the solvent was distilled off in vacuo. The residue was purified by distillation in vacuo, obtaining 163 g of 1-[2-[2-(2-methoxyethoxy)ethoxy]ethyl]-1H-imidazole (boiling point 121° C./16 Pa, yield 76%).

出典