反応 #81009

反応方程式

4-(chloromethyl)-2-cyclopentylthiazole hydrochloride

ethylamine

→

2-Cyclopentyl-4-(((N-ethyl)amino)methyl)thiazole

反応条件

後処理

1. 1
   その他provided
2. 2
   その他after purification of the residue by silica gel chromatography

実験手順

Using the procedure of Example 1Q, but replacing 4-(chloromethyl)-2-isopropylthiazole hydrochloride with 4-(chloromethyl)-2-cyclopentylthiazole hydrochloride and replacing 40% aqueous methylamine with 70% aqueous ethylamine provided, after purification of the residue by silica gel chromatography using 5% methanol in chloroform, 1.08 g (50%) of the desired compound.

出典