反応 #80992

反応方程式

N,N-diethylthiourea

ethyl bromopyruvate

MgSO4

→

desired compound

収率 140.4%

Ethyl 2-(N,N-Diethylamino)thiazole-4-carboxylate

収率 140.4%

溶媒

acetone

反応条件

後処理

1. 1
   温度heated
2. 2
   温度at reflux for 1 h
3. 3
   ろ過The resulting mixture was filtered
4. 4
   濃縮concentrated in vacuo

実験手順

A solution of 0.972 g (7.36 mmol) of N,N-diethylthiourea and 1.02 ml (8.1 mmol) of ethyl bromopyruvate in 25 ml of acetone was treated with excess solid MgSO4 and heated at reflux for 1 h. The resulting mixture was filtered, and concentrated in vacuo. Silica gel chromatography using CHCl3 provided 2.36 g (38%) of the desired compound as an oil. Mass spectrum: (M+H)+ =229.

出典