反応 #80983

反応方程式

4-(chloromethyl)-2-isopropylthiazole hydrochloride

cyclopropylamine

→

desired compound

収率 19.0%

2-Isopropyl-4-(((N-cyclopropyl)amino)methyl)thiazole

収率 19.0%

溶媒

chloroform

反応条件

後処理

1. 1
   濃縮concentrated in vacuo
2. 2
   その他purified by silica gel chromatography

実験手順

A solution of 1.8 g (10.2 mmol) of 4-(chloromethyl)-2-isopropylthiazole hydrochloride in 10 ml of chloroform was added dropwise with stirring to 10 ml of cyclopropylamine. The resulting solution was stirred at ambient temperature for 16 h, concentrated in vacuo, and purified by silica gel chromatography using 5% methanol in chloroform to provide 0.39 g (19%) of the desired compound. 1H NMR (DMSO-d6) δ0.24 (m, 2H), 0.35 (m, 2H),1.30 (d, J=7 Hz, 6H), 2.10 (tt, J=12, 3 Hz, 1H), 3.23 (heptet, J=7 Hz, 1H), 3.77 (s, 2H), 7.21 (s, 1H). Mass spectrum: (M+H)+ =197.

出典