反応 #80920

反応方程式

tributyltin chloride

2-bromo-5-chlorothiophene

n-butyllithium

→

(5-chlorothien-2-yl)tributyl tin

収率 98.1%

溶媒

tetrahydrofuran

tetrahydrofuran

反応条件

後処理

1. 1
   温度The reaction mixture temperature was maintained at -85° C. to -80° C. throughout the addition
2. 2
   workup.ADDITIONUpon completion of addition
3. 3
   workup.ADDITIONUpon completion of addition
4. 4
   温度to warm gradually to ambient temperature
5. 5
   その他The reaction was quenched with an aqueous solution saturated with ammonium chloride
6. 6
   抽出the reaction mixture was extracted with three 150 mL portions of diethyl ether
7. 7
   乾燥The combined extracts were dried with magnesium sulfate
8. 8
   ろ過filtered
9. 9
   濃縮The filtrate was concentrated under reduced pressure

実験手順

A stirred solution of 5.1 mL (0.046 mole) of 2-bromo-5-chlorothiophene in 200 mL of tetrahydrofuran was cooled to -85° C., and 19.7 mL (0.049 mole) of n-butyllithium (0.049 mole-2.5M in hexanes) was added dropwise during a 15 minute period. The reaction mixture temperature was maintained at -85° C. to -80° C. throughout the addition. Upon completion of addition, the reaction mixture temperature was maintained at about -80° C. for one hour. After this time, a solution of 12.5 mL (0.046 mole) of tributyltin chloride in 50 mL of tetrahydrofuran was added to the cold reaction mixture during a 10 minute period. Upon completion of addition, the reaction mixture was stirred at -80° C. for one hour, then it was allowed to warm gradually to ambient temperature. The reaction was quenched with an aqueous solution saturated with ammonium chloride, and then the reaction mixture was extracted with three 150 mL portions of diethyl ether. The combined extracts were dried with magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure, yielding 18.4 grams of (5-chlorothien-2-yl)tributyl tin. The NMR spectrum was consistent with the proposed structure.

出典