反応 #80667

反応方程式

potassium hydroxide

1-cyclohexyloxy-2,2,6,6-tetramethyl-4-acetoxypiperidine

→

1-Cyclohexyloxy-2,2,6,6-tetramethyl-4-hydroxypiperidine

溶媒

methanol

反応条件

後処理

1. 1
   workup.ADDITIONThe mixture is subsequently poured onto ice
2. 2
   抽出extracted with diethyl ether
3. 3
   乾燥After the diethyl ether solution has been dried over sodium sulfate
4. 4
   その他the ether is evaporated
5. 5
   workup.DISSOLUTIONthe viscous residue is dissolved in 300 ml of warm acetonitrile
6. 6
   ろ過The solution is filtered
7. 7
   その他to crystallize

実験手順

24 g (428 mmol) of potassium hydroxide are dissolved in 600 ml of methanol in a conical flask. 85 g (286 mmol) of 1-cyclohexyloxy-2,2,6,6-tetramethyl-4-acetoxypiperidine are poured into the warm solution with stirring. The mixture is subsequently poured onto ice and extracted with diethyl ether. After the diethyl ether solution has been dried over sodium sulfate, the ether is evaporated and the viscous residue is dissolved in 300 ml of warm acetonitrile. The solution is filtered and allowed to crystallize; yield: 50 g (68%). The colourless substance has a melting point of 78.5° C.; purity according to GC analysis: 96%.

出典