反応 #8055

ord-831c0701f36045b3a8991ed9bcbd88f9

反応方程式

CCNCC
diethylamine
COC(=O)c1cc(-c2ccc(F)c(C)c2)nn(CC(C)C)c1=O
( 4 )
COC(=O)c1cc(-c2ccc(F)c(C)c2)nn(CC(C)C)c1=O
6-(4-fluoro-3-methylphenyl)-2-isobutyl-4-methoxycarbonyl-2H-pyridazin-3-one
Cc1cc(-c2cc(COS(C)(=O)=O)c(=O)n(CC(C)C)n2)ccc1F
6-(4-fluoro-3-methylphenyl)-2-isobutyl-4-methanesulfonyloxymethyl-2H-pyridazin-3-one
→
CCN(CC)Cc1cc(-c2ccc(F)c(C)c2)nn(CC(C)C)c1=O
title compound
CCN(CC)Cc1cc(-c2ccc(F)c(C)c2)nn(CC(C)C)c1=O
4-diethylaminomethyl-6-(4-fluoro-3-methylphenyl)-2-isobutyl-2H-pyridazin-3-one

反応物

CCNCC
diethylamine
COC(=O)c1cc(-c2ccc(F)c(C)c2)nn(CC(C)C)c1=O
( 4 )
COC(=O)c1cc(-c2ccc(F)c(C)c2)nn(CC(C)C)c1=O
6-(4-fluoro-3-methylphenyl)-2-isobutyl-4-methoxycarbonyl-2H-pyridazin-3-one
Cc1cc(-c2cc(COS(C)(=O)=O)c(=O)n(CC(C)C)n2)ccc1F
6-(4-fluoro-3-methylphenyl)-2-isobutyl-4-methanesulfonyloxymethyl-2H-pyridazin-3-one

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他were reacted

実験手順

Following the procedure of Example 9 (4), 6-(4-fluoro-3-methylphenyl)-2-isobutyl-4-methanesulfonyloxymethyl-2H-pyridazin-3-one and diethylamine were reacted to yield the title compound as a slightly yellow oil (yield: 94.7%).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07087606B2uspto-grants-2006_08