反応 #803791

ord-3dcf1e25c5e44415a5fca05c8929c813

反応方程式

Cl.Clc1cccc(Cl)c1NC1=NCCN1
clonidine hydrochloride
O=P([O-])([O-])O.[Ca+2]
calcium phosphate dibasic
CCCCCCCCCCCCCCCCCC(=O)[O-].CCCCCCCCCCCCCCCCCC(=O)[O-].[Mg+2]
magnesium stearate
→
Clc1cccc(Cl)c1NC1=NCCN1
Clonidine

反応物

—
hydroxypropyl methyl cellulose
Cl.Clc1cccc(Cl)c1NC1=NCCN1
clonidine hydrochloride
O=P([O-])([O-])O.[Ca+2]
calcium phosphate dibasic
CCCCCCCCCCCCCCCCCC(=O)[O-].CCCCCCCCCCCCCCCCCC(=O)[O-].[Mg+2]
magnesium stearate
—
cellulose

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

Basically 0.1 mg (base equivalent) of clonidine hydrochloride was blended with 13 mg of calcium phosphate dibasic, with 15 mg of microcrystalline cellulose, with 40 mg of hydroxypropyl methyl cellulose, 1 mg of colloidal silica and 0.9 mg of magnesium stearate.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US09192599B2uspto-grants-2015_11