反応 #80324

ord-2bf3a55ffb9740a8a419c4c9f340bd88

反応方程式

COc1cc2ncnc(Cl)c2cc1OC
4-chloro-6,7-dimethoxyquinazoline
Nc1ccc(N)cc1
1,4-phenylenediamine
COc1cc2ncnc(Nc3ccc(N)cc3)c2cc1OC.Cl
4-(4'-aminoanilino)-6,7-dimethoxyquinazoline hydrochloride
収率 85.0%

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

Using an analogous procedure to that described in Example 74, 4-chloro-6,7-dimethoxyquinazoline was reacted with 1,4-phenylenediamine to give 4-(4'-aminoanilino)-6,7-dimethoxyquinazoline hydrochloride in 85% yield, m.p. 274°-276° C.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US05616582uspto-grants-1997_04