反応 #80317

反応方程式

7-(2-bromoethoxy)-6-methoxy-4-(3'-methylanilino)quinazoline

morpholine

→

6-methoxy-4-(3'-methylanilino)-7-(2-morpholinoethoxy)quinazoline

反応条件

後処理

1. 1
   その他The mixture was evaporated
2. 2
   その他the residue was partitioned between methylene chloride
3. 3
   乾燥The organic phase was dried (MgSO4)
4. 4
   その他evaporated
5. 5
   その他The residue was triturated under diethyl ether

実験手順

A mixture of 7-(2-bromoethoxy)-6-methoxy-4-(3'-methylanilino)quinazoline (0.25 g) and morpholine (4 ml) was stirred at ambient temperature for 4 hours. The mixture was evaporated and the residue was partitioned between methylene chloride and a dilute aqueous sodium bicarbonate solution. The organic phase was dried (MgSO4) and evaporated. The residue was triturated under diethyl ether to give 6-methoxy-4-(3'-methylanilino)-7-(2-morpholinoethoxy)quinazoline (0.198 g), m.p. 168°-170° C.

出典