反応 #80295

反応方程式

benzyl 1-benzoyl-5-[(4,6-dimethoxypyrimidin-2-yl)oxy]-3-ethoxycarbonyl-2-methylindol-4-carboxylate

→

desired compound

収率 97.0%

1-Benzoyl-5-[(4,6-dimethoxypyrimidin-2-yl)oxy]-3-ethoxycarbonyl-2-methylindol-4-carboxylic Acid

収率 97.0%

溶媒

ethyl acetate

反応条件

後処理

1. 1
   ろ過Insoluble matters were filtered off
2. 2
   濃縮filtrate was concentrated under reduced pressure
3. 3
   その他The residue thereby obtained
4. 4
   洗浄was washed with isopropyl ether

実験手順

1.6 g of benzyl 1-benzoyl-5-[(4,6-dimethoxypyrimidin-2-yl)oxy]-3-ethoxycarbonyl-2-methylindol-4-carboxylate was dissolved in 50 ml of ethyl acetate, and 0.1 g of 10% palladium carbon was added thereto. Then, catalytic reduction was conducted. Insoluble matters were filtered off, and then filtrate was concentrated under reduced pressure. The residue thereby obtained was washed with isopropyl ether to obtain 1.28 g (yield: 97%) of the desired compound. mp: 113°-115° C.

出典