反応 #80279

反応方程式

benzyl 5-hydroxy-2-methyl-3-methoxycarbonylbenzofuran-4-carboxylate

4,6-dimethoxy-2-methylsulfonyl-1,3,5-triazine

potassium carbonate

→

desired compound

収率 109.7%

Benzyl 5-(4,6-Dimethoxy-1,3,5-triazin-2-yl)oxy-2-methyl-3-methoxycarbonylbenzofuran-4-carboxylate

収率 109.7%

溶媒

N,N-dimethylformamide

反応条件

後処理

1. 1
   温度was heated
2. 2
   その他was returned to room temperature
3. 3
   抽出extracted with ethyl acetate
4. 4
   洗浄The organic layer was washed with water
5. 5
   乾燥dried over anhydrous sodium sulfate
6. 6
   濃縮Then, it was concentrated under reduced pressure
7. 7
   洗浄the obtained solid was thoroughly washed with ethanol

実験手順

A mixture comprising 2 g of benzyl 5-hydroxy-2-methyl-3-methoxycarbonylbenzofuran-4-carboxylate, 1 g of 4,6-dimethoxy-2-methylsulfonyl-1,3,5-triazine and 1 g of potassium carbonate in 20 ml of N,N-dimethylformamide, was heated and stirred at 70° C. for two hours. The mixture was returned to room temperature, poured into ice water and extracted with ethyl acetate. The organic layer was washed with water and then dried over anhydrous sodium sulfate. Then, it was concentrated under reduced pressure, and the obtained solid was thoroughly washed with ethanol to obtain 2.4 g (yield: 86%) of the desired compound.

出典