反応 #80275

反応方程式

water

methyl 5-hydroxybenzoxazol-4-carboxylate

2-chloro-4,6-dimethoxypyrimidine

potassium carbonate

→

desired compound

収率 39.0%

Methyl 5-(4,6-Dimethoxypyrimidin-2-yl)oxybenzoxazol-4-carboxylate

収率 39.0%

溶媒

N,N-dimethylformamide

反応条件

後処理

1. 1
   温度was heated
2. 2
   その他was returned to room temperature
3. 3
   抽出extracted with ethyl acetate
4. 4
   洗浄The organic layer was washed with water
5. 5
   乾燥dried over anhydrous sodium sulfate
6. 6
   濃縮concentrated under reduced pressure
7. 7
   その他The oily substance thereby obtained
8. 8
   その他was purified by silica gel column chromatography (n-hexane/ethyl acetate=5/1)

実験手順

A mixture comprising 0.6 g of methyl 5-hydroxybenzoxazol-4-carboxylate, 0.6 g of 2-chloro-4,6-dimethoxypyrimidine and 0.7 g of potassium carbonate in 30 ml of N,N-dimethylformamide, was heated and stirred at 115° C. for two hours. The mixture was returned to room temperature, then poured into water and extracted with ethyl acetate. The organic layer was washed with water, dried over anhydrous sodium sulfate and then concentrated under reduced pressure. The oily substance thereby obtained was purified by silica gel column chromatography (n-hexane/ethyl acetate=5/1) to obtain 0.4 g (yield: 39%) of the desired compound.

出典