反応 #80273

反応方程式

benzyl 5-(4,6-dimethoxypyrimidin-2-yl)oxy-3-ethoxycarbonyl-2-methylbenzofuran-4-carboxylate

→

desired compound

収率 89.0%

5-(4,6-Dimethoxypyrimidin-2yl)oxy-3-ethoxycarbonyl-2-methylbenzofuran-4-carboxylic Acid

収率 89.0%

溶媒

ethanol

反応条件

後処理

1. 1
   その他After completion of the reaction
2. 2
   その他an insoluble matter was separated by filtration
3. 3
   濃縮the filtrate was concentrated under reduced pressure, whereupon the precipitated crystals
4. 4
   洗浄were washed with a solvent mixture of diethyl ether/n-hexane

実験手順

A mixture comprising 14.4 g of benzyl 5-(4,6-dimethoxypyrimidin-2-yl)oxy-3-ethoxycarbonyl-2-methylbenzofuran-4-carboxylate and 4.52 g of 10% palladium carbon in 100 ml of ethanol, was subjected to hydrogenation under an ordinary pressure while stirring at room temperature. After completion of the reaction, an insoluble matter was separated by filtration, and the filtrate was concentrated under reduced pressure, whereupon the precipitated crystals were washed with a solvent mixture of diethyl ether/n-hexane to obtain 10.47 g (yield: 89%) of the desired compound.

出典