反応 #80261

反応方程式

Methyl 3-bromoadamantaneacetate

Aluminum trichloride

→

methyl 3-phenyl-1-adamantaneacetate

溶媒

benzene

反応条件

後処理

1. 1
   その他The reaction mixture was then quenched by the addition of 0.5M phosphoric acid (1.6 L)
2. 2
   その他The layers were separated
3. 3
   乾燥the organic layer was dried over sodium sulfate
4. 4
   ろ過filtered
5. 5
   その他evaporated in vacuo

実験手順

Methyl 3-bromoadamantaneacetate (80 g) (Aldrich Chemical Co. Milwaukee Wis.) was dissolved in benzene (1.6 L) under nitrogen. Aluminum trichloride (37.12 g) was added portionwise over 75 min. at ambient temperature. The reaction mixture was then quenched by the addition of 0.5M phosphoric acid (1.6 L). The layers were separated and the organic layer was dried over sodium sulfate, filtered, and evaporated in vacuo to give methyl 3-phenyl-1-adamantaneacetate (80 g).

出典