反応 #80258

反応方程式

chloral

hydroxylammonium chloride

hydrochloride

aniline

isatin

→

isonitrosoacetanilide

反応条件

後処理

1. 1
   その他as shown in the following reaction scheme
2. 2
   その他an aqueous solution obtained
3. 3
   その他is reacted for 0.5 to 2 hours
4. 4
   温度with heating at 70° to 110° C.

実験手順

The isatin derivative (9) can be synthesized, for example, as shown in the following reaction scheme. That is, an aqueous solution obtained by adding chloral and hydroxylammonium chloride to hydrochloride of an aniline derivative (10) as a starting material is reacted for 0.5 to 2 hours with heating at 70° to 110° C. to give an isonitrosoacetanilide derivative, and this product is cyclized with concentrated sulfuric acid and hydrolyzed to give an isatin derivative (9). ##STR10## wherein R1A to R1D are as defined above.

出典