反応 #80190

反応方程式

2-(5-Trifluoromethyl-pyridin-2-yl)-benzoic acid isopropyl ester

lithium hydroxide monohydrate

→

title compound

2-(5-Trifluoromethyl-pyridin-2-yl)-benzoic acid

溶媒

tetrahydrofuran-methanol water

反応条件

後処理

1. 1
   workup.ADDITIONwas added
2. 2
   その他the volatiles were removed under vacuum and 5 ml of water
3. 3
   workup.ADDITIONwere added to the mixture, which
4. 4
   抽出The resulting slurry was extracted with ethyl acetate
5. 5
   乾燥the combined organic layers were dried (magnesium sulfate)
6. 6
   ろ過filtered
7. 7
   濃縮concentrated under vacuum

実験手順

2-(5-Trifluoromethyl-pyridin-2-yl)-benzoic acid isopropyl ester was dissolved in 10 ml of a 3:1:1 mixture of tetrahydrofuran-methanol-water, and lithium hydroxide monohydrate (161 mg, 3.84 mmol) was added. After stirring for 3 h at room temperature, the volatiles were removed under vacuum and 5 ml of water were added to the mixture, which was brought to pH 6 with 1N HCl. The resulting slurry was extracted with ethyl acetate, the combined organic layers were dried (magnesium sulfate), filtered and concentrated under vacuum to provide the title compound.

出典