反応 #8001

反応方程式

Intermediate 3

1-[1,2-Dioxo-2-(thien-2-yl)ethyl)-2-piperidinecarboxylic acid

PyBrop

DIEA

2-hydrazino-6-methyl-4-trifluoromethylpyridine

→

title compound

1-(2-Oxo-2-thiophen-2-yl-acetyl)piperidine-2-carboxylic acid N′-(6-methyl-4-trifluoromethyl-pyridin-2-yl)-hydrazide

溶媒

THF

反応条件

実験手順

From Intermediate 3 (267 mg, 1 mmol), 2-hydrazino-6-methyl-4-trifluoromethylpyridine (191 mg, 1 mmol), PyBrop (466 mg, 1 mmol), DMAP (122 mg) and DIEA (2 mL) in THF (30 mL), using the same procedure for Compound 1, the title compound was obtained as a white solid; 110 mg (25%). MS (m/z) 441 (M+1).

出典