反応 #79951

反応方程式

8-cyclopropyl-6-ethynyl-2,2,4,4-tetramethylchroman

triethyl amine

ethyl-2-fluoro-4-iodo phenyl acetate

2-fluoro-4-iodo phenyl acetic acid ethyl ester

Reagent C

2-fluoro-4-iodo phenyl acetic acid ethyl ester

Intermediate 34

8-cyclopropyl-6-ethynyl-2,2,4,4-tetramethylchroman

→

title compound

[4-(8-Cyclopropyl-2,2,4,4-tetramethyl-chroman-6-yl-ethynyl)-2-fluorophenyl] acetic acid ethyl ester

溶媒

tetrahydrofuran

反応条件

実験手順

Following general procedure F and using 8-cyclopropyl-6-ethynyl-2,2,4,4-tetramethylchroman (Intermediate 34, 0.096 g, 0.38 mmol), ethyl-2-fluoro-4-iodo phenyl acetate (Reagent C, 0.104 g, 0.34 mmol), triethyl amine (3 mL), tetrahydrofuran (3 mL), copper(I)iodide (0.020 g, 0.1 mmol) and dichlorobis(triphenylphosphine)palladium(II) (0.060 g, 0.085 mmol) the title compound was obtained (0.14 g, 85%).

出典