反応 #7990

反応方程式

HCl

Aluminum chloride

1-chloro-3-fluoro-2-methoxybenzene

hexanoyl chloride

→

1-(3-chloro-5-fluoro-4-methoxyphenyl)-1-hexanone

反応条件

後処理

1. 1
   温度The mixture warmed
2. 2
   その他partitioned between EtOAc (40 mL) and ice cold water (40 mL)
3. 3
   洗浄The EtOAc layer was washed with brine (30 mL)
4. 4
   乾燥dried over MgSO4
5. 5
   ろ過filtered
6. 6
   その他evaporated under vacuum

実験手順

Aluminum chloride (1.16 g, 8.72 mmol) was added to a stirred mixture of 1-chloro-3-fluoro-2-methoxybenzene (1.00 mL, 8.72 mmol) and hexanoyl chloride (1.47 mL, 10.46 mmol) at room temperature. The mixture warmed and HCl evolution occurred. The resulting mixture was stirred at room temperature for 67 hours and then partitioned between EtOAc (40 mL) and ice cold water (40 mL). The EtOAc layer was washed with brine (30 mL), dried over MgSO4, filtered, and evaporated under vacuum to yield crude 1-(3-chloro-5-fluoro-4-methoxyphenyl)-1-hexanone as an oil.

出典