反応 #7983

反応方程式

HCl

Aluminum chloride

1-fluoro-2-methoxybenzene

hexanoyl chloride

→

1-(3-fluoro-4-methoxyphenyl)-1-hexanone

収率 90.4%

反応条件

後処理

1. 1
   温度The mixture warmed
2. 2
   その他partitioned between EtOAc (100 mL) and water (100 mL)
3. 3
   洗浄The EtOAc layer was washed with water (100 mL), aqueous K2CO3 (100 mL) and brine (50 mL)
4. 4
   乾燥dried over MgSO4
5. 5
   ろ過filtered
6. 6
   その他evaporated under vacuum

実験手順

Aluminum chloride (6.5 g, 48.8 mmol) was added to a stirred mixture of 1-fluoro-2-methoxybenzene (5.0 mL, 44.4 mmol) and hexanoyl chloride (7.5 mL, 53.3 mmol) at room temperature. The mixture warmed and HCl evolution occurred. The resulting mixture was stirred at room temperature for 45 minutes and then partitioned between EtOAc (100 mL) and water (100 mL). The EtOAc layer was washed with water (100 mL), aqueous K2CO3 (100 mL) and brine (50 mL), dried over MgSO4, filtered, and evaporated under vacuum to yield crude 1-(3-fluoro-4-methoxyphenyl)-1-hexanone (9 g) as a solid.

出典