反応 #79763

反応方程式

2-fluorobenzonitrile

4-bromophenol

potassium carbonate

→

2-(4-bromophenoxy)benzonitrile

溶媒

dimethylformamide

反応条件

後処理

1. 1
   温度was heated
2. 2
   workup.WAITto stand overnight at ambient temperature
3. 3
   その他partitioned between ethyl acetate and water
4. 4
   その他The organic layer was separated
5. 5
   洗浄washed
6. 6
   その他dried
7. 7
   その他evaporated
8. 8
   その他to give an oil which
9. 9
   その他The solid was triturated with petroleum ether b.p. 40-60° C.
10. 10
    ろ過filtered

実験手順

A mixture of 2-fluorobenzonitrile (28.8 g), 4-bromophenol (36.9 g), potassium carbonate (58.9 g) and dimethylformamide (30 ml) was heated with stirring under nitrogen at 120° C. for 5 hours. The mixture was allowed to stand overnight at ambient temperature and then partitioned between ethyl acetate and water. The organic layer was separated, washed, dried and evaporated to give an oil which solidified on standing. The solid was triturated with petroleum ether b.p. 40-60° C. and filtered to give 2-(4-bromophenoxy)benzonitrile.

出典