反応 #79569

反応方程式

N-cyclohexylaniline

benzyl isothiocyanate

→

(cyclohexylphenylamino)-N-benzylthiocarboxamide

溶媒

acetonitrile

反応条件

後処理

1. 1
   その他The solvent was removed under reduced pressure
2. 2
   その他the residue purified on preparative silica gel plates

実験手順

To a solution of N-cyclohexylaniline (0.1 ml, 0.57 mmol) in acetonitrile (4 ml) was added a catalytic amount of 4-(dimethylamino)pyridine (5 mg, 0.04 mmol). To this mixture was added benzyl isothiocyanate (0.11 ml, 0.83 mmol) dropwise, and the mixture was stirred at room temperature for 16 hours. The solvent was removed under reduced pressure, and the residue purified on preparative silica gel plates, developing with 20% ethyl acetate/hexanes, to furnish (cyclohexylphenylamino)-N-benzylthiocarboxamide as a white solid, (M+1)=324.8.

出典