反応 #7955
ord-95e98eaea1a94f0591c92261b6aa3074
反応方程式
反応物
試薬
反応条件
後処理
- 1workup.ADDITIONwas added by syringe
- 2温度to slowly warm to room temperature
- 3workup.STIRRINGstirred at room temperature overnight
- 4抽出The aqueous phase was extracted with more EtOAc (20 mL)
- 5洗浄The combined organics were washed with 5% NaHCO3, water, and brine
- 6乾燥dried over MgSO4
- 7ろ過filtered
- 8濃縮concentrated under vacuum to a yellow oil
- 9その他The crude product was purified by preparative layer chromatography (PLC) on a 0.1×20×20 cm silica gel GF plate
- 10抽出The band at Rf 0.44-0.56 was extracted with EtOAc
- 11その他the extracts evaporated under vacuum
実験手順
A solution of 9a-butyl-7-methoxymethoxy-4-methyl-1,2,9,9a-tetrahydro-3H-fluoren-3-one (162 mg, 0.52 mmol) in anhydrous THF (2.5 mL) was cooled in an ice bath and stirred under a nitrogen atmosphere while 0.4M LDA in THF (1.55 mL, 0.62 mmol) was added by syringe. After stirring at 0° C. for 30 minutes, the solution was cooled to −78° C. (dry ice-acetone bath) and treated with iodomethane (0.162 mL, 2.6 mmol). The resulting mixture was allowed to slowly warm to room temperature, then stirred at room temperature overnight. The mixture was diluted with EtOAc (60 mL) and shaken with saturated aqueous NH4Cl (40 mL). The aqueous phase was extracted with more EtOAc (20 mL). The combined organics were washed with 5% NaHCO3, water, and brine, dried over MgSO4, filtered, and concentrated under vacuum to a yellow oil. The crude product was purified by preparative layer chromatography (PLC) on a 0.1×20×20 cm silica gel GF plate using 4:1 hexanes-EtOAc as developing solvent. The band at Rf 0.44-0.56 was extracted with EtOAc and the extracts evaporated under vacuum to provide (2SR,9aSR)-9a-butyl-2,4-dimethyl-7-methoxymethoxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one (111 mg) as an oil.