反応 #79417

反応方程式

(6-Chloropyrido[3,4-d]pyrimidin-4-yl)-(4-(3-fluorobenzyloxy)-phenyl)-amine

5-(1,3-dioxolan-2-yl)-2-(tributylstannyl)-furan

→

(6-(5-(1,3-Dioxolan-2-yl)-furan-2-yl)-pyrido[3,4-d]pyrimidin-4-yl)-(4-(3-fluorobenzyloxy)-phenyl)-amine

溶媒

dioxan

反応条件

後処理

1. 1
   その他The mixture was evaporated
2. 2
   ろ過This was then filtered through Celite®
3. 3
   その他the solvent evaporated
4. 4
   その他The gummy residue was then triturated with hexane giving a beige solid (1.74 g)

実験手順

(6-Chloropyrido[3,4-d]pyrimidin-4-yl)-(4-(3-fluorobenzyloxy)-phenyl)-amine (1.85 g) and 5-(1,3-dioxolan-2-yl)-2-(tributylstannyl)-furan (3.82 g) in dioxan (40 ml) were reacted together as in Procedure B. The mixture was evaporated and the residue suspended in dichloromethane. This was then filtered through Celite® and the solvent evaporated. The gummy residue was then triturated with hexane giving a beige solid (1.74 g); m/z 485 (M+1)+.

出典