反応 #79415

反応方程式

(6-Chloropyrido[3,4-d]pyrimidin-4-yl)-(4-(4-fluorobenzyloxy)-phenyl)-amine

5-(1,3-dioxolan-2-yl)-2-(tributylstannyl)-furan

→

(6-(5-(1,3-Dioxolan-2-yl)-furan-2-yl)-pyrido[3,4-d]pyrimidin-4-yl)-(4-(4-fluorobenzyloxy)-phenyl)-amine

溶媒

dioxan

反応条件

後処理

1. 1
   その他The mixture was evaporated
2. 2
   ろ過This was then filtered through celite
3. 3
   その他the solvent evaporated
4. 4
   その他The gummy residue was then triturated with hexane giving a beige solid (1.21 g)

実験手順

(6-Chloropyrido[3,4-d]pyrimidin-4-yl)-(4-(4-fluorobenzyloxy)-phenyl)-amine (1.82 g) and 5-(1,3-dioxolan-2-yl)-2-(tributylstannyl)-furan (3.75 g) in dioxan (40 ml) were reacted together as in Procedure B. The mixture was evaporated and the residue suspended in dichloromethane. This was then filtered through celite and the solvent evaporated. The gummy residue was then triturated with hexane giving a beige solid (1.21 g); m/z 485 (M+1)+.

出典