反応 #792153

反応方程式

2-chloro-3-trifluoromethylpyridine

3-trifluoromethylpyrazole

potassium carbonate

→

title compound

収率 62.2%

3-Trifluoromethyl-2-[3-(trifluoromethyl)-1H-pyrazol-1-yl]pyridine

収率 62.2%

溶媒

反応条件

後処理

1. 1
   その他The cooled reaction mixture
2. 2
   抽出The mixture was extracted twice with ether (100 mL)
3. 3
   洗浄the combined ether extracts were washed twice with water (100 mL)
4. 4
   乾燥The organic layer was dried with magnesium sulfate
5. 5
   濃縮concentrated to an oil

実験手順

A mixture of 2-chloro-3-trifluoromethylpyridine (3.62 g., 21 mmol), 3-trifluoromethylpyrazole (2.7 g., 20 mmol), and potassium carbonate (6.0 g, 43 mmol) were heated at 100° C. for 18 h. The cooled reaction mixture was added to ice/water (100 mL). The mixture was extracted twice with ether (100 mL) and the combined ether extracts were washed twice with water (100 mL). The organic layer was dried with magnesium sulfate and concentrated to an oil. Chromatography on silica gel with hexanes:ethyl acetate 8:1 to 4:1 as eluent gave the title compound (3.5 g) as an oil.

出典