反応 #792145

反応方程式

(E)-1-(2-hydroxy-4-isobutoxyphenyl)-3-(pyridin-2-yl)prop-2-en-1-one

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final compound

収率 84.7%

1-(2-hydroxy-4-isobutoxyphenyl)-3-(pyridine-2-yl)propan-1-one

収率 84.7%

溶媒

EtOAc

反応条件

後処理

1. 1
   その他was conducted at atmospheric pressure room temperature until the starting material
2. 2
   ろ過The catalyst was filtered
3. 3
   その他the crude was purified by chromatography on silica gel (25% EtOAc/hexane)

実験手順

In a 200 mL round-bottomed flask, (E)-1-(2-hydroxy-4-isobutoxyphenyl)-3-(pyridin-2-yl)prop-2-en-1-one (1.08 g, 3.63 mmol) and 80 mg of 10% Pd/C was mixed together in wet EtOAc (50 ml). Hydrogenation was conducted at atmospheric pressure room temperature until the starting material was gone. The catalyst was filtered and the crude was purified by chromatography on silica gel (25% EtOAc/hexane) to provide 0.92 g of final compound (82%) as off white solid.

出典