反応 #792140

反応方程式

sodium hydroxide

triazole

2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-ethyl-oxirane

N-methyl-2-pyrrolidon

ammonium chloride

→

2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-(1,2,4-triazol-1-yl)butan-2-ol

反応条件

後処理

1. 1
   抽出the mixture extracted with MTBE
2. 2
   洗浄washed with an aqueous solution of lithium chloride
3. 3
   その他The crude residue was purified by recrystallization in diisopropylether

実験手順

To 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-ethyl-oxirane (216.0 g, 0.63 mol) dissolved in N-methyl-2-pyrrolidon (2 L) was added sodium hydroxide (62.87 g, 1.57 mol) and triazole (217.1 g, 3.14 mol) at room temperature. The mixture was then stirred for 12 hours at 140° C. A solution of ammonium chloride and ice water was then added, the mixture extracted with MTBE and washed with an aqueous solution of lithium chloride. The crude residue was purified by recrystallization in diisopropylether to give 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-(1,2,4-triazol-1-yl)butan-2-ol compound as a colorless solid (127.0 g, 51%; m.p.=140-142° C.).

出典